Pure red cell aplasia due to follow-on epoetin

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Epoetin-induced autoimmune pure red cell aplasia.

During the first 10 yr of therapy with recombinant human erythropoietin ([EPO]), only three cases of antibody-associated pure red cell aplasia have been described in patients who were treated with EPO, whereas several millions of patients have received this treatment. Thus, the possibility for epoetin to induce the formation of anti-EPO antibodies was considered extremely low. However, since 19...

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Epoetin alfa (Eprex): reports of pure red blood cell aplasia.

© 2002 Canadian Medical Association or its licensors Reason for posting: Health Canada has alerted health care professionals of a letter issued by Janssen-Ortho Inc. warning of serious postmarketing adverse events associated with the anemia drug epoetin alfa (Eprex). Seven cases of pure red cell aplasia (PRCA) have been reported in Canada after an estimated 80 000 patient-years of exposure to t...

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Pure red cell aplasia induced by epoetin zeta

Pure red cell aplasia (PRCA) may develop in patients with chronic kidney disease receiving erythropoiesis-stimulating agents (ESA). We report on a 72-year-old patient who developed hypo-proliferative anaemia unresponsive to ESA following the administration of epoetin zeta subcutaneously for 7 months. On the basis of severe isolated hypoplasia of the erythroid line in the bone marrow and high-ti...

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Studies on Pure Red Cell Aplasia

An 1 8-yr-old female with chronic active The patient’s plasma was cytotoxic for hepatitis developed a severe anemia due erythroblasts. Following splenectomy, a to a lack of red cell production. Her bane remission of the disease occurred. This marrow showed many large proerythrostudy indicates that in some cases the blasts but an almost complete lack of more anemia associated with abundant marro...

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Studies on Pure Red Cell Aplasia . VII .

An 1 8-yr-old female with chronic active The patient’s plasma was cytotoxic for hepatitis developed a severe anemia due erythroblasts. Following splenectomy, a to a lack of red cell production. Her bane remission of the disease occurred. This marrow showed many large proerythrostudy indicates that in some cases the blasts but an almost complete lack of more anemia associated with abundant marro...

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ژورنال

عنوان ژورنال: Kidney International

سال: 2008

ISSN: 0085-2538

DOI: 10.1038/ki.2008.230